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Jiladia, Meeta A.
- Estimation of Gatifloxacin in Tablet Dosage Form by Spectrofluorimetric Method
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Authors
Affiliations
1 Veerayatan Institute of Pharmacy, Jakhania Bhuj, Mandvi Road, Mandvi-370640, IN
2 Babaria Institute of Pharmacy, Vadodara-391240, IN
3 Jiladia Hospital, New Anjar, Anjar (Kutch)-370110, IN
1 Veerayatan Institute of Pharmacy, Jakhania Bhuj, Mandvi Road, Mandvi-370640, IN
2 Babaria Institute of Pharmacy, Vadodara-391240, IN
3 Jiladia Hospital, New Anjar, Anjar (Kutch)-370110, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 58-59Abstract
Three simple and sensitive spectrofluorimetric methods have been developed for the determination of gatifloxacin and its tablet dosage forms. In fluorescence spectrum of gatifloxacin exhibit excitation and emission wavelength at 295 and 498 nm in hydrochloric acid, 295 and 489 nm in acetate buffer pH-4 and 337 and 488 nm, in phthalate buffer pH-4, respectively. The fluorescence intensity for all three methods was found to be linear with the concentration in the range of 200-1000 ng/ml. The % recovery for gatifloxacin was found in the range of 97.0-102.6% in hydrochloric acid, 99.5-100.2% in acetate buffer, 98.3–100.1% in phthalate buffer. These methods were found to be simple, accurate, reproducible and economical and can be used for the routine analysis of gatifloxacin in bulk drug and its tablets.Keywords
Gatifloxacin, Hydrochloric Acid, Acetate Buffer, Phthalate Buffer pH-4.- Estimation of Rosiglitazone in Bulk and Tablet Dosage Forms by HPTLC Method
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Authors
Affiliations
1 Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi-370460, IN
2 Babaria Institute of Pharmacy, Vadodara-391240, IN
3 Jiladia Hospital, New Anjar, Anjar (Kutch)-370110, IN
1 Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi-370460, IN
2 Babaria Institute of Pharmacy, Vadodara-391240, IN
3 Jiladia Hospital, New Anjar, Anjar (Kutch)-370110, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 1 (2010), Pagination: 26-28Abstract
A simple and sensitive, HPTLC method has been developed for the quantitative estimation of rosiglitazone in its single component tablet formulations (4 mg). Rosiglitazone was chromatographed on silica Gel 60 F254 TLC plate using Toluene:acetone: ammonia (4.5:5.5:0.1 v/v) as mobile phase. Rosiglitazone showed Rf value 0.55±0.03 and scanned at 318 nm using Camag TLC Scanner 3. The method was validated in terms of linearity (200-2000 ng/spot), precision (intra-day variation 0.6 to 3.6%, inter-day variation 0.6 to 3.0%), accuracy (98.1 to 103.3%) and specificity. The limit of detection and limit of quantification for rosiglitazone were found to be 30 ng/spot and 100 ng/spot, respectively. The developed method was successfully used for the assay of rosiglitazone tablet formulations. The method is simple, sensitive and precise;it can be used for the routine quality control testing of marketed formulations.Keywords
Rosiglitazone, Toluene, Acetone, Ammonia, HPTLC.- A Simple and Sensitive HPTLC Method for Estimation of Pioglitazone In Bulk and Tablet Dosage Forms
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Authors
Affiliations
1 Veerayatan Institute of Pharmacy, Jakhania Bhuj-Mandvi Road, Mandvi- 370640 (Gujarat), IN
2 Babaria Institute of Pharmacy, Vadodara – 391240 (Gujarat), IN
1 Veerayatan Institute of Pharmacy, Jakhania Bhuj-Mandvi Road, Mandvi- 370640 (Gujarat), IN
2 Babaria Institute of Pharmacy, Vadodara – 391240 (Gujarat), IN